Healthspan.

Advanced · 10 min read

NAD+ & Cellular Energy Protocol

What the research says about NAD+ precursors, who might benefit, and how to cycle them.

  1. 01

    Understand the evidence

    NAD+ declines with age. NR and NMN raise blood NAD+ in humans; clinical outcomes are still being studied.

  2. 02

    Start low

    250–500mg per day in the morning. Assess energy and sleep for 4–6 weeks.

  3. 03

    Pair with exercise

    Exercise itself boosts NAD+ — supplements are not a substitute.

  4. 04

    Consider metabolic tracking

    A CGM can show how your energy correlates with diet and timing.

Recommended for this protocol

NAD+Moderate evidence

Nicotinamide Riboside

ExampleBio · $40/mo · ★ 4.4

  • + Multiple human trials
  • + Raises NAD+ reliably
  • − Pricier per gram
Check price →
NAD+Emerging evidence

NMN 500mg

ExampleLabs · $45/mo · ★ 4.3

  • + Third-party tested
  • + Sublingual option
  • − Human data still limited
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WearableEmerging evidence

Continuous Glucose Monitor

LevelsCo · $199/mo · ★ 4.2

  • + Real-time food feedback
  • − Expensive
  • − 14-day sensors
Check price →